Analysis of miR-155 Expression in Prostate Cancer Patients

Abstract

Objective: Prostate cancer is a major global health issue and the second most common cancer in men. Its
pathogenesis involves genetic and epigenetic changes, hormonal imbalances, and environmental factors,
with deficiencies in double-strand break repair mechanisms playing a critical role. microRNAs (miRNAs) are
small, non-coding RNA molecules that regulate gene expression post-transcriptionally and are implicated
in cancer-related processes.

Methods: microRNA-155 expression was analyzed in paired tumor and normal tissues from 50 patients with
pathologically confirmed prostate cancer (PC) using quantitative reverse transcription polymerase chain
reaction (qRT-PCR). In addition, clinical parameters such as age, smoking status, diabetes, hypertension,
PIRADS scores, and Gleason scores were evaluated for their potential association with miR-155 expression.

Results: No statistically significant difference was observed in miR-155 expression between tumor and
normal tissues (P > .05). Moreover, miR-155 levels did not show significant correlation with any of the
evaluated clinical factors.

Conclusion: These findings suggest that miR-155 may not play a direct role in the development and progression of PC. However, this study contributes to the growing understanding of the relationship between
PC, DNA repair mechanisms, and miRNA regulation. Further studies with larger cohorts and standardized
methodologies are needed to clarify the potential of miR-155 as a biomarker or therapeutic target in PC.

Cite this article as: Habibi S, Rouhi V, Baykal Koca S, Köseoğlu H, Güven M. Analysis of miR-155 expression in prostate cancer
patients. Cerrahpaşa Med J 2025, 49, 0008, doi: 10.5152/cjm.2025.25008.