Original Article

Vol. 1 No. 0 (2019): Cerrahpaşa Medical Journal

Does anterior commissure involvement change the selection of treatment modality in early-stage glottic larynx cancer?

Main Article Content

Meltem Dağdelen
Haydar Murat Yener
Muhammed Veysel Hekim
Merve Şahin
Fırat Tevetoğlu
Sinem Kara Peker
Chinara Aliyeva
Yetkin Zeki Yılmaz
Emine Deniz Gözen
Emin Karaman
Günay Can
Ömer Erol Uzel

Abstract

Objective: Glottic laryngeal cancers are detected at an early stage at the time of diagnosis. Radiotherapy (RT) or transoral laser microsurgery (TLM) as a local treatment is a choice for early glottic laryngeal cancer. This study aims to investigate the local control rate after RT or TLM for early-stage glottic laryngeal cancer  (ESLC) with anterior commissure involvement.



Methods: 119 patients with early-stage (Tis-T1-2) laryngeal cancer were treated in our institution with RT or TLM between 2009 -2021. The median follow-up time was 52 months. Seventy-three patients underwent TLM. Forty-six patients received RT, and there were 41 patients with anterior commissure involvement.



Results: The 2 and 5 years overall survival (OS) rates were 92% and 73%, whereas local failure-free survival (LFFS) rates were  84% and 82% in all groups, respectively. The 2-year OS was 88% in the RT arm and 94% in the TLM arm, respectively. There was no statistically significant difference between the two treatment groups for OS (p: 0.062). According to anterior commissure involvement, twenty-nine underwent TLM, whereas 12 patients received radiotherapy. A total of 9 local failures occurred in the TLM group, there was no recurrence in the RT group (p:0.028).



Conclusion: There was no statistically significant difference between the two treatment groups for LFFS, and OS. However, in the case of the anterior commissure involvement, 9 local failures occurred in the TLM group, and there was no recurrence in the RT group. RT might be recommended in ESLC, especially in patients with anterior commissure involvement.

 


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