Review

The genetics of pain

Volume 41 · Issue 1 Publish Date: November 11, 2013
Full Text PDF
DOI
Ali Ferit Pekel
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Anesteziyoloji Anabilim Dalı Ağrı Bilim Dalı, İstanbul image/svg+xml
Pekel, A. F. (2013). The genetics of pain. Cerrahpaşa Medical Journal, 41(1), 32–38. https://doi.org/10.2399/ctd.10.032
Full Text Full Text PDF

Abstract

Individuals are unique as in their fingerprints. Shared features among people, regarding social and culturel issues constitutes ethnic and national societies while common biological features lead to shared treatment strategies. Details of our shared and differing emotional/physical attitudes rely muchly upon what we inherited genetically. Once identified the sequenced human genom, the reasons of the individual varience of human response to external effects became more clear. In pain management it is reflected as individual variation in both to response to pain and response to anagesics. This is probably produced by the multiple single-nucleotide polymorphisms –SNPs- in genes encoding drug metabolism enzymes, transporters, receptors, ion channels, and neurotransmitter systems. This novel explanation to known subjective pain experience is increasingly questioning the appropriateness of previously established conventional pain management strategies, asking; whether it is possible to produce drugs spesific for the subgroups of any society? Maybe the final question will dare to ask if human will be tailored by means of analgesics ?!..

Article Info
Published In
Journal Cerrahpaşa Medical Journal
Volume / Issue Volume 41 · Issue 1
Pages 32-38
History
Published Online November 11, 2013
Copyright
Affiliations
Ali Ferit Pekel
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Anesteziyoloji Anabilim Dalı Ağrı Bilim Dalı, İstanbul
Cite this Article
Pekel, A. F. (2013). The genetics of pain. Cerrahpaşa Medical Journal, 41(1), 32–38. https://doi.org/10.2399/ctd.10.032
Outlines