KRONİK TİNER İNHALASYONUNUN SIÇAN AKCİĞER VE KARACİĞER DOKULARI LİPİD PEROKSİDASYONLARINA ETKİSİ

Abstract

Background and Design.­ We studied the effect of chronic thinner inhalation (during 5 weeks) on lipid peroxidation in the lung and liver of the rats. Additionally, we studied superoxide dismutase (SOD) activities and reduced glutathione (CSH) levels.

Results.­ Significant increases were found in lipid peroxidation (TBA RS) levels of rats which had inhaled thinner compared to those of the control group (p=0.000). As opposed to increases in the TBA­RS levels, significant decreases in the SOD activities and GSH levels were observed when compared to the rats in the control group (p=0.000).

Conclusion.­ Increases in peroxidative damage due to the reactive oxygen species generation and decreases in the antioxidant capacity may be the cause of some progressive dysfunction in these tissues.