Cerrahpaşa Medical Journal
ORIGINAL ARTICLE

The Effect of Orphenadrine on Rewarding Property of Morphine-Induced Conditioned Place Preference

1.

Department of Medical Pharmacology, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey

2.

Department of Medical Pharmacology, Haliç University School of Medicine, İstanbul, Turkey

Cerrahpasa Med J 2020; 44: 80-85
DOI: 10.5152/cjm.2020.20003
Read: 392 Downloads: 126 Published: 11 May 2020

Objective: Orphenadrine (Orp), an anti-cholinergic drug, is subjected to drug abuse and dependence in recent years. This experiment was designed to study the effect of Orp on rewarding and reinforcing properties of morphine-induced conditioned place preference (CPP).

Methods: Rats were randomly divided into six groups as control (serum physiological), morphine (10 mg/kg), Orp (20 mg/kg and 30 mg/kg), and Orp + morphine (20 mg/kg, 30 + 10 mg/kg, respectively). After pretest, the rats were given multiple intraperitoneal injections of saline solution and Orp on alternative days.

Results: Morphine significantly enhanced the preference scores in the drug-paired side (p<0.001), whereas both groups with doses of Orp (20 mg/kg and 30 mg/kg) did not exhibit any preference compared with the control group. Orp (30 mg/kg) + morphine showed no preference, whereas Orp (20 mg/kg) + morphine significantly decreased the CPP when compared with morphine group (p<0.01). The combined used of Orp (20 mg/kg) + morphine reduced the preference, whereas Orp (30 mg/kg) + morphine did not exhibit acquisition of CPP in rats.

Conclusion: The acquisition of CPP is thought to be due to N-methyl D-aspartate receptor antagonistic effects of Orp at low dose. It is thought that the rewarding feature or abuse potential should be analyzed in further investigation.

Cite this article as: Köse Ç, Shahzadi A, Akkan AG, Özyazgan S. The Effect of Orphenadrine on Rewarding Property of Morphine-Induced Conditioned Place Preference. Cerrahpaşa Medical Journal 2020; 44(2): 80-85.

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