Cerrahpaşa Medical Journal
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Serum YKL-40 and Cardiovascular Diseases

1.

Department of Cardiology, Gaziantep Islamic Science and Technology University, Gaziantep, Türkiye

2.

Department of Cardiology, Siirt Education and Research Hospital, Siirt, Türkiye

Cerrahpasa Med J 2024; 48: 185-190
DOI: 10.5152/cjm.2024.23078
Read: 200 Downloads: 175 Published: 17 July 2024

Abstract: YKL-40 is a glycoprotein synthesized by several cell types, including macrophages, neutrophils, and endothelial cells. It plays a role in several biological processes, such as tissue remodeling, inflammation, and cell proliferation. Research findings have shown that levels of YKL-40 tend to be higher in individuals diagnosed with cardiovascular diseases (CVDs), including atherosclerosis. Elevated concentrations of YKL-40 have been associated with detrimental CV outcomes. In general, while the precise function of YKL-40 in CVDs is still under investigation, it is evident that this glycoprotein has significant potential as a biomarker for CVDs. Furthermore, CVD treatment has the potential to specifically target the protein YKL-40.

Cite this article as: Aşkın L, Tanrıverdi O. Serum YKL-40 and cardiovascular diseases. Cerrahpaşa Med J. 2024;48(2):185-190.

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