Cerrahpaşa Medical Journal
ORIGINAL ARTICLE

Does Anterior Commissure Involvement Change the Selection of Treatment Modality in Early-Stage Glottic Larynx Cancer?

1.

Department of Radiation Oncology, Istanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey

2.

Department of Ear, Nose and Throat Diseases, Istanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey

3.

Department of Radiation Oncology, Erzurum Regional Education and Research Hospital, Erzurum, Turkey

4.

Department of Ear, Nose and Throat Diseases, Amasya Merzifon Kara Mustafa Paşa State Hospital, Amasya, Turkey

5.

Department of Ear, Nose and Throat Diseases,Sisli Türkiye Hospital, Istanbul, Turkey

6.

Department of Public Health, Istanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey

Cerrahpasa Med J 2023; 47: 285-290
DOI: 10.5152/cjm.2023.22132
Read: 500 Downloads: 264 Published: 14 December 2023

Objective: Glottic laryngeal cancers are detected at an early stage at the time of diagnosis. Radiotherapy or transoral laser microsurgery as a local treatment is a choice for early-stage glottic laryngeal cancer. This study aims to investigate the local control rate after radiotherapy or transoral laser microsurgery for early-stage glottic laryngeal cancer with anterior commissure involvement.

Methods: In total, 119 patients with early-stage (Tis-T1-2) laryngeal cancer were treated in our institution with radiotherapy or transoral laser microsurgery between 2009 and 2021. The median follow-up time was 52 months. Seventy-three patients underwent transoral laser microsurgery. Forty-six patients received radiotherapy, and there were 41 patients with anterior commissure involvement.

Results: The 2 and 5 years overall survival rates were 92% and 73%, whereas local failure-free survival rates were 84% and 82% in all groups, respectively. The 2-year overall survival was 88% in the radiotherapy arm and 94% in the transoral laser microsurgery arm, respectively. There was no statistically significant difference between the two treatment groups for overall survival (P: .062). According to anterior commissure involvement, 29 underwent transoral laser microsurgery, whereas 12 patients received radiotherapy. A total of 9 local failures occurred in the transoral laser microsurgery group, there was no recurrence in the radiotherapy group (P: 0.028).

Conclusion: There was no statistically significant difference between the two treatment groups for local failure-free survival and overall survival. However, in the case of the anterior commissure involvement, 9 local failures occurred in the transoral laser microsurgery group, and there was no recurrence in the radiotherapy group. Radiotherapy might be recommended in early-stage glottic laryngeal cancer, especially in patients with anterior commissure involvement.

Cite this article as: Dağdelen M, Yener HM, Hekim MV, et al. Does anterior commissure involvement change the selection of treatment modality in early-stage glottic larynx cancer? Cerrahpaşa Med J. 2023;47(3):285-290.

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