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Background.- Cutaneous emergency is not so frequent. But some cutaneous adverse drug reactions are frequent, occurring in 3% of hospitalized patients. There are some important diseases as toxic shock syndrome, every cause of erythroderma, angio-oedema and some cutaneous infections, inflammations, collagenous diseases need early diagnosis and convenient management. Otherwise a very large spectrum of autoimmune disorders is subject matter of urgent conditions in dermatological practice.