Cerrahpaşa Medical Journal

Correlation Between Prostate-Specific Antigen Density and Findings from Multiparametric Magnetic Resonance Imaging of Prostate


Department of Radiology, Ankara Atatürk Sanatoryum Training and Research Hospital, Ankara, Turkey


Department of Radiology, Karabük Training and Research Hospital, Karabük, Turkey

Cerrahpasa Med J 2022; 46: 189-193
DOI: 10.5152/cjm.2022.22048
Read: 1094 Downloads: 269 Published: 11 October 2022

Objective: The present study is intended to investigate the relationship between multiparametric prostate magnetic resonance findings and prostatespecific antigen density in the diagnosis of prostate cancer.

Methods: The present study included 38 cases that underwent multiparametric prostate magnetic resonance between January 1, 2019, and February 28, 2022. Age, prostate-specific antigen, transrectal ultrasound biopsy, prostate-specific antigen density, and prostate imaging-reporting and data system results of all cases were recorded. Together with the prostate-specific antigen density threshold value, the sensitivity and specificity of prostate-specific antigen density and prostate imaging-reporting and data system scores in predicting histopathological outcomes were calculated.

Results: Of the patients undergoing transrectal ultrasound biopsy, 11 patients (28.9%) were diagnosed with prostate cancer. The median prostatespecific antigen density was higher in the group of malignant cases [0.2 (0.1-1.9) ng/mL2] than in the group of non-malignant cases [0.1 (0.03- 0.57) ng/mL2] (P < .0001). With the prostate-specific antigen density threshold value set at 0.16 ng/mL2, the sensitivity was 73% and the specificity was 89% in predicting prostate cancer, while positive predictive value was 73% and negative predictive value was 89% (area under the curve: 0.864, P < .001). Multiparametric prostate magnetic resonance findings had a sensitivity of 91% and a specificity of 85%, as well as positive predictive value of 71% and negative predictive value of 96% in predicting prostate cancer (P < .001). There was a strong correlation with the biopsy result in the prostate imaging-reporting and data syste m/pro state -spec ific antigen density positive group (Rho: 0.79, P < .0001) where the sensitivity, specificity, and negative predictive value were found to be 100%, 78%, and 100%, respectively.

Conclusion: The results of the present study demonstrated that the combined use of prostate-specific antigen density and multiparametric prostate magnetic resonance imaging helps obtain more robust results in diagnosing prostate cancer, compared to using either of them individually.

Cite this article as: Öztürk C, Güngör Ö, Ersay H, Uysal Ramadan S. Correlation between prostate-specific antigen density and findings from multiparametric magnetic resonance imaging of prostate. Cerrahpaşa Med J. October 4, 2022. 2022;46(3):189-193.

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