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Background and Design. We aimed to study the relation between liver injury or gliadin antibodies and human leukocyte antigens. The 30 celiac disease patients were included in our study. The mean age of study population was 5.8 years; 20 being female. The HLAA, B, DR and DQ antigens were studied by the lymphocytotoxic reaction.
Results. The children aged 2 years and below with gliadin antibodies above 50 AU, were not positive for HLAA32, B 16, B5, DQ4, DQ6(1) and DR14(6) antigens. HLAB4 antigen was more frequent and HLADR7 was significantly absent among the children older than 2 years who also had gliadin IgA antibodies above 50 AU. Similarly, among the children above 2 years with IgG gliadin antibodies above 50 AU, HLAA1, A9, B17, B37, B73 and DR9 had highly significant negative association with celiac disease. The celiac patients who had HLA A11; B18, B40 and DQ1 did not show aspartate aminotransferase elevation.
Conclusion. We conclude that there is a relation between human leukocyte antigens and aminotransferases and gliadin antibody levels.